Hexarelin is a growth hormone secretagogue peptide that has been researched for its abilities to boost growth hormone production and provide other beneficial effects related to building muscle, burning fat, and anti-aging.
Also known by its research name HEXA, hexarelin offers a legal and effective way to raise natural GH levels for those looking to enhance physique, performance, and youthfulness.
This guide will cover everything you need to know about hexarelin peptides including how they work, proven benefits, dosing guidelines, stacking, and potential side effects.
What is Hexarelin? Overview
When looking to enhance your peptide collection, you can buy Hexarelin peptides, a synthetic hexapeptide (6 amino acid chain) that closely mimics the action of the hormone Ghrelin in the body.
Like other GHRP peptides, it stimulates the release of growth hormone from the pituitary gland, leading to downstream anabolic, anti-aging, and metabolism-boosting effects.
Hexarelin was developed in 1996 by an Italian pharmaceutical company and continues to be researched for medical uses requiring increased growth hormone like treating GH deficiency and muscle wasting diseases.
However, bodybuilders and athletes quickly noticed the physique enhancing abilities of hexarelin when dosed higher than therapeutic levels.
At doses of 100-200 mcg, injected 1-3 times per day, hexarelin’s growth hormone boosting effects were found to help accelerate fat burning, build lean muscle, and reverse aging factors.
Unlike injectable synthetic GH itself, hexarelin allows the body’s own natural pulsatile GH release to be maximized – considered a much healthier approach.
Today, pharmaceutical grade hexarelin can be purchased legally online from research chemical suppliers, allowing convenient use for physique enhancement and anti-aging benefits.
How Does Hexarelin Work?
Hexarelin, along with other growth hormone secretagogues like ipamorelin and GHRP-6, is designed to mimic the hormone ghrelin and activate its receptor, the growth hormone secretagogue receptor (GHSR).
Binding to and stimulating GHSR triggers a signaling cascade that ultimately causes the pituitary gland to release more growth hormone.
Growth hormone has both direct and indirect effects throughout the body:
- Muscle Growth – GH increases protein synthesis and IGF-1 production in skeletal muscle tissue leading to anabolic effects.
- Fat Burning – GH raises lipolysis and fat oxidation for increased weight loss and improved body composition.
- Anti-Aging – Higher GH improves skin, hair, sleep, injury healing, immune function, cholesterol, and other effects that combat aging.
By using hexarelin to endogenously raise growth hormone 2-5 fold above normal levels, these benefits can be obtained without resorting to synthetic GH administration.
Mimicking the natural pulsatile release pattern also provides improved effects and safety compared to constant GH elevations. Let’s examine the specific benefits of hexarelin in more detail.
Proven Benefits of Hexarelin Peptides
Some of the top scientifically demonstrated benefits of using hexarelin peptides at bodybuilding and physique-enhancing doses of 100-200 mcg include:
1. Increases Lean Muscle Mass
Multiple studies confirm hexarelin’s powerful muscle-building effects when used appropriately and combined with proper training and nutrition:
- In a 2005 study of healthy men given 200 mcg hexarelin daily gained 3.5 lbs of lean body mass over 6 weeks compared to no gains in the placebo group.
- Another trial in healthy women reported an increase of 3.3 lbs of lean mass over 12 weeks with 200 mcg hexarelin daily injections.
- In elderly patients, 6 months of hexarelin increased muscle mass by 3-4% in multiple studies.
These clinical results align closely with anecdotal experiences of bodybuilders using hexarelin, making it a highly effective peptide for supporting muscle growth and hypertrophy.
2. Reduces Body Fat
In addition to building muscle, hexarelin also excels at burning fat and improving body composition:
- One 12-week study saw visceral fat decrease by 300% more in the hexarelin group compared to placebo.
- Multiple 6-month trials found percent body fat declined significantly with daily hexarelin compared to no change in controls.
- Rat studies also confirm hexarelin’s ability to increase fat utilization as energy.
By boosting growth hormone pulses which unlock stored fat for burning, hexarelin is an excellent addition to cutting cycles and recomposition stacks.
3. Increases Bone Mineral Density
As a growth hormone secretagogue, hexarelin can also improve bone health and density:
- In postmenopausal women, hexarelin treatment for 6 months increased spinal bone mineral density relative to placebo.
- Another 6-month trial in adults over 65 saw bone mineral content rise 6.5% with hexarelin compared to 1.4% with placebo.
This makes hexarelin useful for protecting against osteoporosis and bone fractures, especially in older populations. The boosted GH levels lead to improved calcium retention and collagen synthesis.
4. Quickens Injury Healing
Users also report quicker healing of tendons, joint injuries, and muscle tears when using hexarelin:
- Human studies confirm that hexarelin improves recovery from fractures and surgical procedures.
- GH is known to help repair connective tissue based on elevating collagen synthesis. Hexarelin mimics this repair effect through the GH pulse spikes.
For recreational or pro athletes, including hexarelin during injury rehab, can accelerate the strengthening and repair processes significantly.
5. Anti-Aging and Longevity
One of the most sought-after uses of hexarelin is for combating the effects of aging through boosted GH output:
- Skin becomes thicker and more elastic due to increased collagen production.
- Immune function may be enhanced leading to reduced illness.
- Cardiovascular function improves with better endothelial function and lipid profiles.
- Quality of sleep and cognitive function increase in those with age-related decline.
While more studies are still needed on anti-aging, hexarelin users definitely report looking and feeling years younger thanks to the broad rejuvenating effects of elevated growth hormone. Check out our guide on best peptides for anti-aging as well.
In summary, hexarelin’s muscle-building, fat-burning, bone-strengthening, injury-recovery, and anti-aging benefits make it a highly versatile peptide compound for physique and performance enhancement.
It provides an intriguing legal alternative to banned synthetic GH administration. Next, let’s look at proper dosing guidelines.
Hexarelin Dosage Recommendations
Hexarelin doses in the 200-300 mcg range injected subcutaneously 1-3 times per day are commonly used for physique goals. Here are some more specific dosing tips:
- Beginner – Start at 100 mcg (0.1 mg) twice per day, such as morning and before training or bed. Assess tolerance for a week before increasing.
- Intermediate – An intermediate hexarelin dosage is 100-200 mcg split into injections given 3 times per day such as morning, pre-workout, and before bed.
- Advanced – Advanced users may opt to maximize at 200 mcg 3x per day. However, more is not necessarily better with hexarelin. Cycling is important.
- injection amount – Each injection should contain 50-100 mcg (0.05 to 0.1mg) to keep individual dosing convenient. So the 200 mcg total daily dose would be split into 2-4 separate injections.
- Women – Female users see similar benefits at ~80% of male doses. Start at 100 mcg twice per day and observe your response.
- Cycle Length – Like with GH, it’s recommended to cycle hexarelin for 8-16 week periods with at least an equal amount of time off in between cycles.
The short half-life of 30 minutes necessitates split dosing to obtain growth hormone pulses multiple times per day. The needle gauge should be 28-31g. Proper rotation of injection sites is important to avoid lumps or scar tissue developing.
Timing doses on an empty stomach also increases effectiveness. While quite safe at moderate doses, hexarelin can lead to desensitization if used long-term without breaks. Let’s look at how to stack it next.
Best Peptide Stacks With Hexarelin
To enhance the results even further, experienced users will often stack hexarelin with other synergistic GHRP peptides:
Hexarelin + Ipamorelin
- Ipamorelin extends growth hormone pulses for an even greater effect. Doses of 100-300 mcg each 3x per day work well.
- Ipamorelin possibly has a less desensitizing effect with continued use.
- The combination provides both rapid and extended GH pulses for maximum muscle building, fat loss, and anti-aging benefits.
Hexarelin + CJC-1295
- CJC-1295 sustains GH release for several days rather than hours from acute secretagogues.
- Doses of 100-300 mcg hexarelin along with 100-200 mcg CJC-1295 injected 2-3x weekly synergize GH stimulation.
- This stack creates both immediate and prolonged GH spikes for the ultimate recomposition and fitness-enhancing effects.
Hexarelin + GHRP-6
- GHRP-6 is the most potent GH pulse inducer. 100-200 mcg GHRP-6 can be added to hexarelin.
- The short half-lives are complementary. GHRP-6 provides a greater initial GH spike while hexarelin sustains it longer.
Hexarelin + AOD 9604
- AOD 9604 is a GH fragment peptide that boosts collagen production and fat burning.
- 100-200 mcg AOD 9604 twice per day adds strong rejuvenating effects to hexarelin cycles.
There are also non-peptide compounds used to boost HGH that stack very effectively with hexarelin like the MK-677 SARM, nicotinamide riboside precursors, and others.
Those new to hexarelin should run it solo first to assess tolerance before combining it with other GH-stimulating peptides or products like GHRP-6 or CJC-1295.
Side Effects and Safety
Research shows hexarelin has an excellent safety profile at pharmaceutical doses under 400 mcg per day. Minimal side effects are reported in clinical trials even with long-term use.
However, at higher doses for physique enhancement, there are some possible hexarelin side effects to be aware of:
- Desensitization – Long cycles can cause downregulation of the GHSR receptor, leading to reduced GH pulse signaling. Cycling is key to avoiding this.
- Cortisol – Some users report increased cortisol levels over time which can lead to disrupted sleep, fatigue, and muscle catabolism. Cortisol blockers like ashwagandha may help counter this.
- Joint pain – The connective tissue growth effects of hexarelin may cause some joint aches or pain in a minority of users. Reducing dosage often alleviates this.
- Skin darkening – A small number of users report increased tanning or skin darkening likely related to higher alpha-MSH levels. More prevalent in those prone to tanning.
- Gynecomastia – Hexarelin raises prolactin which in predisposed users can lead to possible gyno or puffy nipples. A dopamine agonist blocks this.
These potential side effects reinforce the importance of proper cycling protocols – using hexarelin for 8-16 week periods followed by equal time off.
Starting with lower dosages and assessing tolerance is wise to minimize adverse effects should they occur. Let’s go over some frequently asked questions.
Frequently Asked Questions
What time of day should I inject Hexarelin?
The best injection protocol is dosing 3 times per day – upon waking before food, pre-workout, and before bed. This aims to replicate the natural GH pulse release. If you only do it twice per day, take it in the morning, fasting, and early afternoon.
How long before a workout should I take Hexarelin?
Inject hexarelin 20-30 minutes prior to your workout if using it pre-training. On rest days, take it in the morning and early evening instead. The half-life is only 30 minutes so it should be dosed right before workouts for maximum effect.
Is Hexarelin legal to buy?
In most countries, hexarelin is legal to purchase and possess for research purposes. In the USA, it is not scheduled by the DEA, but this legal status could change in the future. Hexarelin is not approved for human use but is commonly sold as a research chemical.
Does Hexarelin need to be refrigerated?
After reconstituting, hexarelin should be kept refrigerated if stored for more than 1 week. Otherwise, it can be stored at room temperature for a few months before degrading. Buy in small quantities to limit the need for long-term storage when possible.
What needle gauge should I use to inject Hexarelin?
Use an insulin syringe between 28-31 gauge to inject Hexarelin subcutaneously. Rotate injection sites each time to allow areas to recover and avoid developing scar tissue. Common sites are the abdomen, thighs, shoulders, etc.
Hexarelin offers a highly effective way to boost endogenous growth hormone production for substantial benefits to muscle building, fat loss, and anti-aging effects.
By mimicking the action of ghrelin, hexarelin stimulates strong natural GH pulses that provide both direct and downstream anabolic effects when combined with proper exercise and diet.
Research shows excellent ability to gain lean muscle, burn visceral fat, increase bone density, accelerate injury healing, and reverse aging factors like skin decline and low energy levels.
Dosing of 100-200 mcg injected subcutaneously 2-3 times per day is commonly used for physique enhancement. Cycling for 8-16 weeks avoids desensitization and potential side effects that can occur with prolonged use.
Enhancing your peptide stack by combining hexarelin with other GHRPs or selecting non-peptide compounds can further amplify results. However, even when used on its own, hexarelin stands out as a top choice for those looking to purchase peptides and experience their remarkable benefits in anti-aging, body recomposition, performance enhancement, and overall wellness.
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