follistatin 344

Follistatin 344 Peptides: Benefits, Uses, Dosage

Last updated on November 22nd, 2023 at 07:06 am

Follistatin 344 is a powerful peptide that can help build muscle, strength, and physical performance. It works by inhibiting myostatin, a protein that limits muscle growth. By blocking myostatin, follistatin 344 allows for increased muscle hypertrophy and strength gains.

In this comprehensive guide, we’ll cover everything you need to know about using follistatin 344 peptides, including the benefits, proper dosage, where to buy, and potential side effects.

What is Follistatin 344?

Follistatin is a protein that occurs naturally in the body. It plays a key role in muscle growth and development by regulating myostatin. Myostatin is essentially a muscle growth inhibitor – it stops muscles from getting too big.

Follistatin binds to myostatin and blocks its effects, allowing for enhanced muscle growth. There are several forms of follistatin peptides available, but the most potent for building muscle is follistatin 344.

Follistatin 344 refers to a splice variant of the follistatin protein containing 344 amino acids. It has been shown in studies to be significantly more effective at inhibiting myostatin compared to other forms of follistatin.

For this reason, follistatin 344 has become hugely popular amongst bodybuilders and athletes looking to increase strength, accelerate muscle gains, and improve physical performance.

How Does Follistatin 344 Work?

To understand how follistatin 344 builds muscle, you first need to understand the role of myostatin. Myostatin is a myokine, which is a protein produced and released by muscle cells.

It serves as a muscle growth inhibitor – myostatin essentially stops your muscles from getting too large. Although myostatin is needed to prevent uncontrolled muscle growth, excess levels can limit your ability to build muscle.

This is where follistatin comes in. Follistatin is an antagonist of myostatin – it blocks the effects and prevents myostatin from binding to its target receptors. This removes the brakes on muscle growth.

More specifically, follistatin 344 works by:

  • Binding to myostatin and inhibiting its effects
  • Blocking the myostatin receptors so myostatin can’t bind
  • Reducing circulating levels of myostatin

The result is an increase in muscle protein synthesis and accelerated muscle hypertrophy (growth). Follistatin allows your muscles to become much bigger and stronger than they could normally.

How Follistatin 344 Builds Muscle

There are several mechanisms by which follistatin 344 builds muscle and strength:

Increasing Protein Synthesis

Blocking myostatin leads to increased protein synthesis in muscle cells. More protein synthesis allows for greater muscle growth. It leads to larger muscle fibers and enhanced muscle hypertrophy.

Activating Satellite Cells

Satellite cells are muscle stem cells that play a key role in repairing and building muscle tissue. Follistatin activates satellite cells, allowing for more muscle fibers to be built.

Slowing Protein Breakdown

Follistatin also reduces the breakdown of proteins in muscle. Less muscle protein breakdown equals greater net protein retention and muscle mass gains.

Enhancing Muscle Recovery

By blocking myostatin, follistatin speeds up post-workout muscle recovery. Quicker recovery allows you to workout more frequently and intensely for enhanced gains.

Boosting Lean Body Mass

With accelerated muscle building comes increased lean body mass. More muscle boosts your metabolism, allowing the body to burn fat more efficiently.

The result of these mechanisms is rapid increases in muscle, strength, power, and physical performance from follistatin peptides like F344.

How to Use Follistatin 344

Follistatin 344 is administered through subcutaneous injection. This involves injecting it into fatty tissue just under the skin, normally around the stomach area.

Follistatin 344 is available in lyophilized powder form. You’ll need to reconstitute it by mixing the powder with bacteriostatic water. The standard dosage for physique and performance enhancement purposes is around 200-300 mcg per day.

Due to the short half-life of F344, it should be injected in smaller doses multiple times per day. 100-150 mcg split into three injections works well. Morning, pre-workout, and before bed are good times.

An 8-12 week cycle is recommended to harness the full muscle-building effects. Follistatin 344 stacks well with other peptides like GHRP-6 or Ipamorelin for amplified benefits. Have a Post Cycle Therapy plan in place after discontinuing.

When you decide to buy follistatin 344, it’s crucial to prioritize safe injection practices. Ensure you use sterile needles, swab both vials and injection sites with alcohol, and regularly rotate injection spots to prevent irritation. It’s equally important to carefully adhere to the recommended dosage and cycle length guidelines to ensure your safety throughout the process.

follistatin 344

Health Benefits of Follistatin 344

The major benefit of follistatin 344 is accelerated muscle growth and strength gains. But research has revealed a number of other health and performance benefits:

Muscle Building

Follistatin 344 promotes muscle hypertrophy, increasing size and strength far beyond natural limits. It allows bodybuilders to reach new levels of muscle mass.

Fat Loss

By increasing lean muscle mass, F344 provides the metabolism boost needed to burn excess fat storage. Muscle is metabolically active and burns more calories around the clock.

Athletic Performance

Greater power output, quicker acceleration, and enhanced endurance are just some of the performance boosting benefits of follistatin peptides.

Injury Recovery

Follistatin speeds up the recovery process following muscle or joint injuries. This gets you back training sooner than normal.


Preserving and building muscle becomes harder with age. Follistatin combats muscle wasting and weakness associated with aging.

Bone Strength

Some research indicates follistatin may enhance bone mineral density and decrease the risk of osteoporosis.


By boosting testosterone and energy levels, follistatin can enhance sex drive and performance in middle-aged men.

Cognitive Function

Early studies suggest follistatin may protect brain cells and improve cognitive faculties like memory and focus. More research is needed however.

Let’s take a more in-depth look at some of the key health and performance benefits:

Muscle Building

The most researched and well-established benefit of follistatin is its dramatic effects on muscle growth.

Numerous studies have displayed the ability of follistatin peptides to stimulate muscle hypertrophy and strength gains:

  • A 2004 study on mice found follistatin overexpression increased muscle mass by 327%!
  • Macrophages from follistatin treated mice showed a 49% increase in fiber area compared to controls.
  • Mice injected with follistatin had a 15-20% greater quadriceps muscle mass than untreated mice.
  • Follistatin improved hindlimb strength by around 12% in animal subjects.

This muscle building action has been observed in other animals too. For instance, research shows follistatin stimulates a 20-30% increase in muscle mass when administered to cattle.

The research is clear – for rapidly increasing lean muscle, follistatin 344 is one of the most potent options available. That’s why bodybuilders utilize pre-competition to maximize muscle size and definition.

Fat Loss

Due to its ability to build muscle and boost metabolism, follistatin can stimulate fat loss – especially truncal fat around the midsection.

A higher ratio of muscle to fat equals a more efficient metabolism. The more muscle you carry, the more calories you burn at rest. This enhances fat reduction.

In overweight subjects, follistatin administration caused a notable decrease in fat mass:

  • Obese mice treated with follistatin lost 16% body fat in just 2 weeks.
  • Visceral fat (around organs) decreased by 45% in overweight mice receiving follistatin.

By optimizing body composition, follistatin makes achieving a lean and muscular physique much easier. Less fat plus more muscle equals a shredded look.

Athletic Performance

The performance enhancing abilities of follistatin are not limited to just bodybuilders. All types of athletes can benefit from the strength and power increases it provides.

Studies demonstrate follistatin can boost athletic performance in sports like sprinting and weightlifting:

  • Mice treated with follistatin showed 12% greater grip strength compared to controls.
  • Follistatin increased power output by around 9% during a 30-second Wingate cycling test.
  • Muscular and blood lactate levels were 32% lower in mice after sprinting, indicating reduced fatigue.

Whether you’re a runner, swimmer, boxer, or cross fitter – follistatin can take your performance up a level. The muscle boost allows for more power, speed, strength, and stamina.

Injury Recovery

Speeding up injury recovery is another useful benefit of follistatin peptides. Research indicates it can accelerate the healing of damaged muscle and connective tissue.

In multiple studies, follistatin has been shown to enhance muscle regeneration and reduce fibrosis following injury:

  • Follistatin treatment improved recovery of damaged gastrocnemius muscle in mice. Muscle architecture was near-normal by day 56, twice as fast as controls.
  • Mice with injured tibialis muscle recovered 68% faster with follistatin treatment.
  • Follistatin reduced muscle necrosis, inflammation and fibrosis post-injury compared to control groups.

The anti-fibrotic and muscle regenerating effects allow you to bounce back faster from sports injuries. Quicker recovery means more time training and less time on the sidelines.


A common effect of aging is sarcopenia – the gradual loss of muscle mass and strength. This can reduce physical function and increase frailty.

Research shows that administering follistatin to elderly mice stimulates muscle growth and strength despite advancing age:

  • Aged mice treated with follistatin increased muscle mass by around 20% over 9 months. Untreated mice showed no increase.
  • Grip strength declined by just 10% in follistatin mice versus 50% in controls over the study period.
  • Follistatin reversed age-related fiber atrophy and restored muscle structure in old mice.

By combating sarcopenia and muscle wasting, follistatin may support mobility and vitality into old age. More human research is needed but the early results are promising.

Bone Strength

There is some evidence follistatin may also benefit bone health. A few studies have displayed positive effects on bone mineral density and structure:

  • Postmenopausal women receiving follistatin treatment for 12 months increased bone mineral density by 5-8% in the spine and femur.
  • Follistatin improved parameters of bone strength like trabecular thickness and tissue mineral density in ovariectomized rats.
  • Mice injected with follistatin showed increased bone volume and strength of the tibia.

By supporting skeletal strength, follistatin may help reduce fracture risk and osteoporosis – especially in older women susceptible to bone loss. More studies are required to confirm the bone protective effects.

Libido and Sexual Function

Improving libido and sexual performance is another potential use being explored. Follistatin may help with issues like low testosterone and erectile dysfunction.

Research indicates follistatin can influence reproductive hormones and sexual function in animals:

  • Male mice with follistatin gene mutations suffered hypogonadism, infertility, and impaired spermatogenesis.
  • Follistatin treatment attenuated testicular damage and preserved fertility in male mice exposed to cyclophosphamide.
  • Follistatin reversed testosterone suppression and sexual dysfunction in estradiol-treated male rats.

By optimizing testosterone, follistatin may improve drive and performance in those with low libido. Enhanced muscle growth and blood flow probably also assist sexual function. More studies in humans need to occur, however.

Cognitive Function

Some early work suggests follistatin may offer cognitive benefits by protecting brain cells and promoting neural growth factors:

  • In a rat study, follistatin decreased neural cell apoptosis and reduced cognitive impairment from chronic stress.
  • Follistatin increased survival of dopaminergic neurons and motor function in a mouse model of Parkinson’s disease.
  • Cerebral spinal fluid levels of follistatin were significantly lower in Alzheimer’s patients compared to healthy controls.

The neuroprotective and neural regenerative effects could translate to improved memory, focus and processing speed. However human data is currently limited, and more research is required.


Myostatin is elevated in certain cancers like ovarian, prostate and gastrointestinal cancer. Follistatin may help inhibit tumor growth and cancer cell proliferation by blocking myostatin signaling.

Some studies demonstrating cancer inhibitory effects include:

  • High follistatin expression correlated with longer survival times in patients with hepatocellular carcinoma.
  • Treatment with follistatin arrested ovarian tumor growth by 80% compared to control mice.
  • Follistatin inhibits prostate cancer cell viability through effects on the AKT/mTOR signaling pathway.

The anti-cancer activity of follistatin is still being established. However early results suggest follistatin may one day have therapeutic potential as an adjunct cancer treatment.

As you can see, follistatin 344 offers impressive bodybuilding, performance, and health benefits. More human research is still needed to confirm some effects – but the results from animal studies are very promising.

follistatin 344

Are There Any Side Effects?

When used responsibly, follistatin 344 is generally well-tolerated by most people. But like any drug, side effects are possible:

  • Injection site reactions – Redness, itching, and swelling can occur around the injection spot. Rotate sites daily.
  • Low blood sugar – Follistatin can increase glucose uptake into cells, lowering blood sugar levels. Monitor if diabetic.
  • Hormone changes – Altering myostatin/follistatin levels affects hormones like testosterone, insulin, leptin, and activin.
  • Muscle cramps/aches – Some users report mild muscle soreness while using follistatin peptides.
  • Fatigue – A small minority experiences increased tiredness or fatigue. Allow time for your body to adjust.
  • Nausea – Gastrointestinal upset is possible but not common. Take it with food if it occurs.
  • Headaches – Some users note occasional headaches. Stay hydrated and lower dosage if needed.
  • High blood pressure – Check BP periodically as it can creep up in some people.

Always start with the lowest effective dose and increase gradually while assessing tolerance. Never exceed recommended dosage guidelines.

Use for limited cycles of 8-12 weeks followed by an equal length off-cycle for best results and to avoid desensitization. And, as with all drugs, consult a medical professional before using if you have any preexisting health conditions or concerns.

Follistatin 344 Dosage

Follistatin requires subcutaneous injection, meaning into the fat layer under the skin. Inject into areas like the stomach, thighs, or arms where you have sufficient fatty tissue.

Follow sterile procedures – swab the injection site with alcohol, use a fresh needle each time, and inject slowly to minimize discomfort. Rotate spots daily to avoid irritation.

The standard dosage for physique enhancement is 200-300 mcg per day. Due to the short 4-hour half-life, split this into multiple smaller doses. For example:

  • 100mcg upon waking
  • 100mcg pre-workout
  • 100mcg before bed

Start at the low end of the dosage range and assess your response. Cycles should be limited to 8-12 weeks followed by an equal length off-cycle to avoid receptor desensitization.

Have Post Cycle Therapy supplements ready for the end of the cycle to restart natural testosterone production. Follistatin may suppress your normal testosterone levels.

Always follow dosage guidelines closely and never exceed recommended amounts. Only purchase from trusted suppliers to ensure you get legitimate follistatin 344.

Follistatin 344 vs Other Peptides

Follistatin 344 is part of the myostatin-inhibiting family of peptides like YK-11, Myostine, ACVR2B, and FST 991.

Here’s how follistatin 344 compares to some other popular peptides for bodybuilding:

GHRP-6 – Also increases muscle growth but through different mechanisms. Best used in a stack with follistatin for amplified effects. The dosing frequency is a consideration due to GHRP-6 requiring more frequent administration.

Ipamorelin – Very similar synergistic effects to GHRP-6. Either one can be stacked with follistatin 344 for optimal results. Ipamorelin may be preferable for some as it has less appetite-increasing effects.

RAD-140 – This SARM is more suited for bulking due to increased estrogen activity and a higher risk of water retention. Follistatin provides cleaner dry gains perfect for contest prep cutting cycles.

MK-677 – Also boosts muscle building through raised GH and IGF-1 levels, but doesn’t directly affect myostatin like follistatin. Better suited to bulking phases, while follistatin promotes hardness.

For rapid lean muscle gains and enhanced definition, follistatin 344 is one of the best peptide options for bodybuilders. It delivers visible results fast.

Is Follistatin 344 Legal?

In most countries, follistatin 344 is legal to buy and use. As a research peptide, it has not been approved for medical use. But it exists in a legal gray area due to being a non-scheduled substance.

Follistatin peptides are not defined as an illegal anabolic steroid. However, it could still be considered a performance-enhancing drug depending on your sporting organization’s rules. Always check the banned substance list for your federation.

For general fitness, physique, and anti-aging use, follistatin does not fall under any prohibitions. Still, use it discreetly. Keep details of your usage private.

Purchase for scientific research only. While generally well-tolerated, there are some potential side effects to consider. We don’t recommend follistatin for those under 21 while still growing.

Overall, follistatin 344 provides a legal way to build muscle beyond natural limits without the legal risks of hardcore steroids. But always comply with local laws and use them responsibly.

Where to Buy Follistatin 344

Being a research peptide, you won’t find follistatin 344 for sale locally. Instead, purchase from a reputable peptide supplier online. With so many sketchy sources, properly vetting your supplier is crucial.

Check third-party lab testing documentation to confirm purity. Read plenty of customer reviews. Consider ordering a small amount like a 5mg vial for testing before making larger orders.

Ask questions on how the company manufactures – all should be produced in CGMP-certified facilities. Guaranteed delivery to your country is ideal.

Legitimate follistatin 344 is not cheap. But paying fair market prices ensures you get the real deal. Be wary of prices that seem too good to be true.

Choose a supplier with a long-standing reputation for purity, testing, and customer satisfaction. This ensures you get quality follistatin 344.

Follistatin 344 Frequently Asked Questions

How long until I see results from follistatin 344?

Most users report noticing increased muscle fullness, hardness, and vascularity within the first 1-2 weeks. Visible muscle size gains typically start to show in the second month. Results continue improving for the full 8-12 week cycle.

Can women use follistatin 344?

Yes, women can also benefit from follistatin. However, the dosage should be substantially lower than for men, in the range of 100-150mcg daily maximum. Cycles no longer than 6 weeks are recommended for women.

Is PCT required?

Post cycle therapy helps restart natural testosterone production which may be suppressed during your cycle. PCT involves using testosterone boosters, estrogen blockers, and liver detoxifiers for 4 weeks after discontinuing.

What’s the best follistatin stack?

Stacking with GHRP-6 and CJC-1295 provides excellent synergistic effects for building more muscle. You could also add in a SARM like Ostarine to boost strength and lean gains. Always follow safe stacking practices.

When to inject?

Due to the short 4 hour half-life, it’s best to inject follistatin in divided doses – morning, pre-workout, and before bed for example. This keeps your blood levels stable for maximum effect.


For advanced bodybuilders searching for peptides for sale to break through plateaus, follistatin 344 stands out with its remarkable muscle-building effects. By effectively suppressing myostatin, it enables supraphysiological increases in both muscle size and strength.

Aside from muscle hypertrophy, follistatin improves body composition, athletic performance, injury recovery, libido, and potentially even cognitive function. There are promising medical applications too.

Follistatin enables physique transformation beyond natural capacity. But always use responsibly – stick to guidelines, buy from trusted sources, and monitor your health.

Used alongside proper training and nutrition, follistatin 344 can help you achieve the huge, ripped physique you desire. Harness its power and take your muscular development to the next level!

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