Enclomiphene citrate is a selective estrogen receptor modulator (SERM) that has become popular for boosting testosterone levels and improving symptoms of secondary hypogonadism in men.
By blocking estrogen receptor activity in the brain, Enclomiphene stimulates increased production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland. This drives increased testosterone secretion by the testes.
When taking Enclomiphene, it typically takes around 2 weeks for peak blood levels to build up before positive effects on testosterone are observed. Enclomiphene is generally well-tolerated in most men when used responsibly under medical supervision, but there are some important factors to consider for safety and maximizing benefits.
Potential side effects of Enclomiphene may include increased libido, acne, irritability, headaches, nausea, or other hormonal effects. High doses can increase the risk of side effects, so it’s important to buy Enclomiphene Citrate in the appropriate dosage and use the lowest effective dose, monitoring your response closely. Working with a doctor to maintain optimal Enclomiphene levels minimizes potential issues.
The key is being an informed patient, tracking your progress on Enclomiphene closely, sticking to prescribed dosing guidelines, reporting any concerning symptoms, and getting follow-up bloodwork to ensure your hormones are balancing safely and effectively.
Things to Do While Taking Enclomiphene
1. Start with a Low Dose
When using Enclomiphene for the first time, it’s best to start with a very low dose such as 6-12 mg per day and gradually increase from there while assessing your response.
This allows your body to become accustomed to the effects slowly and gives you time to watch for potential side effects before ramping up the dosage. Starting too high too quickly increases risk of unwanted issues emerging.
2. Take Daily with Food
To keep blood levels stable, Enclomiphene should be taken once per day with food. The fatty acids in a meal help increase its absorption.
Splitting into twice daily doses may provide more stable levels, but for convenience most stick to once a day. Taking at the same time each day also helps maintain consistency.
An hour before or after your workout is ideal timing to capitalize on the heightened anabolic state.
3. Monitor Changes and Side Effects
When running any cycle, it’s essential to closely monitor both the positive and negative changes to your body and health. This includes keeping track of benefits like increased strength, muscle pump, endurance, energy, libido, and fat loss.
But also monitor for potential side effects like headache, nausea, visual changes, infertility, gyno, acne, aggression, hormone imbalances, cholesterol changes, liver enzymes, or heart issues. Report any concerning or serious symptoms to your doctor.
4. Drink Plenty of Water
Staying well hydrated is important when using any supplement or steroid that affects hormone balance and metabolism. Aim for at least 1-2 gallons of water daily, and more if sweating heavily from training.
Proper hydration aids liver detoxification, keeps blood pressure balanced, transports nutrients, regulates body temperature, lubricates joints, and keeps energy levels high. Don’t rely on thirst to dictate water intake.
5. Follow a Nutritious Diet
Your diet needs to be on point to fuel training and recovery when using a compound like Enclomiphene. Focus your nutrition on whole foods with plenty of protein, healthy fats, fiber, micronutrients, fruits, and vegetables.
Limit intake of processed foods, excess salt, sugars, and saturated fats. Getting sufficient but not excessive calories is key – use a moderate surplus of around 300 calories above maintenance to build quality lean mass.
6. Prioritize Sleep
Your body produces the majority of its testosterone and growth hormone at night during deep sleep. When using Enclomiphene, it’s especially important to optimize sleep quantity and quality.
Aim for at least 7-9 hours per night, with consistent bed and wake times. Limit blue light and digital stimulation close to bedtime. Create an ideal sleep environment that is cool, dark and comfortable. Consider supplements like melatonin, glycinese or CBD.
7. Manage Stress
Chronic stress raises cortisol which can reduce testosterone and suppress your immune system. When using Enclomiphene, it’s vital to keep stress in check through relaxation practices, fun hobbies, socializing, therapeutic outlets, and taking time for yourself.
Don’t overdo cardio which elevates cortisol. Practice deep breathing, meditation, yoga, massage, sauna, gratitude journaling, or nature time to lower stress long-term. Talk to a counselor if needed.
8. Perform Compound Lifts
Your training regimen should focus on heavy compound exercises while taking Enclomiphene to maximize the muscle and strength building potential. Squats, deadlifts, bench press, overhead press, bent over rows, and pull-ups should form the foundation.
Use a moderately high volume with increased weight and lower reps for the prime muscle building rep range of 6-12 reps per set. Take 2-3 minutes rest between sets. Train each major muscle group 2-3x per week.
9. Add Cardio and Conditioning
While prioritizing heavy weights, it’s also beneficial to add some cardio and conditioning to improve work capacity, endurance, athleticism, fat burning, lung capacity, heart health, and circulation.
Aim for 2-4 moderate cardio sessions per week like jogging, biking, rowing, swimming, sports, sled pushes, tire flips, sprints, and active recovery. Don’t overdo long steady-state cardio which can impair mass gains.
10. Avoid Oral Consumption
One of the most important tips is to avoid ingesting Enclomiphene orally. The liver toxicity and side effects are much greater with oral consumption compared to injections, gels, or transdermal solutions.
Never take Enclomiphene in tablet form – always use a sterile injectable or properly dosed topical gel or liquid with safe solvents like DMSO or PEG. This bypasses the liver and GI tract.
11. Avoid Stacking Multiple Compounds
When using a powerful hormone-influencing substance like Enclomiphene, it’s usually best avoided stacking multiple compounds together during the same cycle.
Adding other drugs like SARMs or prohormones increases the risk of side effects exponentially. Only introduce one new substance at a time and assess your response before considering stacking. More is not always better.
12. Don’t Drink Alcohol
Alcohol should be avoided as much as possible when using Enclomiphene since it stresses the liver, dehydrates the body, and lowers testosterone over time. It also reduces protein synthesis rates needed for optimal muscle repair and growth.
If you do drink, limit intake to 1-2 light drinks, avoid binge drinking, and allow several days between alcohol consumption to prevent liver strain and hormone disruption.
Safely Coming Off Enclomiphene
Discontinuing Enclomiphene requires a proper transition plan to avoid hormonal crashes or losing your gains too quickly. Here are some tips:
- Taper your dosage over 1-2 weeks, don’t stop abruptly
- Use an estrogen antagonist like arimistane to counter estrogen rebound
- Get follow-up blood work 4 weeks later to verify hormone recovery
- Expect to lose some strength and size gains, but retain much of the muscle with hard training
- Wait at least 2 months before considering another Enclomiphene cycle
- Shift focus to higher rep training and cardio work during the time off cycle
- Clean up your diet, limit alcohol, optimize sleep habits, and minimize life stresses
- Be patient – your hormones and body will normalize if you give it proper time to recover after each cycle
With an informed and responsible approach, Enclomiphene can be used to enhance athletic performance and muscle building. But its unapproved status requires extra precautions.
Always work under medical supervision, monitor your health, avoid stacking multiple compounds, does conservatively, and cycle off periodically. Your long-term health is the top priority.
Here are answers to the requested questions about Enclomiphene:
What does Enclomiphene do?
Enclomiphene is a selective estrogen receptor modulator (SERM) that acts on the hypothalamus and pituitary gland in the brain to increase the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This stimulates the testes to produce more testosterone. It’s used to treat low testosterone and infertility in men.
Is Enclomiphene safe?
More research is still needed on the long-term safety of Enclomiphene. Short term studies have found it can effectively increase testosterone with minimal side effects in most men. However, there are risks of potential side effects like other hormonal drugs. It’s not FDA approved for safety and efficacy. Caution is advised with using Enclomiphene without medical supervision.
What are side effects associated with using Enclomiphene?
Reported side effects of Enclomiphene may include:
- Nausea or upset stomach
- Visual changes or disturbances
- Mood changes like irritability or depression
- Breast tenderness or enlargement
- Skin reactions like acne or rash
- Hot flashes
- Changes in liver enzymes or cholesterol levels
- Joint pain or stiffness
- Sleep problems like insomnia
Higher doses increase chances of side effects. Long-term safety needs further research. Those with existing health conditions should use caution when using any non-FDA approved drug.
What other drugs interact with Enclomiphene?
Enclomiphene may potentially interact with:
- Estrogens or anti-estrogens like tamoxifen or raloxifene
- Androgens or anabolic steroids
- Opioid pain medications
- Thyroid hormones
- Insulin or diabetes medications
- Cholesterol lowering statins
- Blood pressure medications
- Some herbal supplements like St. John’s wort
Concomitant use of multiple hormones or drugs can increase risk of complications. Tell your doctor about any medications you take with Enclomiphene and closely monitor health. Avoid mixing Enclomiphene with anything that also influences hormone levels.
- Kaminetsky J, Werner M, Fontenot G, Wiehle RD. Oral Enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone. Fertility and Sterility. 2013 Oct 31;100(4):S398.
- Wiehle RD, Fontenot GK, Wike J, Hsu K, Nydell J, Lipshultz LI, Sigman M. Enclomiphene citrate enhances anaerobic glycolysis and improves quality of spermatogenesis in men with idiopathic oligospermia. Fertility and Sterility. 2014 Sep 1;102(3):e237.
- Wiehle RD, Palmer JS, Werner M, Fontenot GK, Hsu K, Nydell J, Lipshultz LI, Sigman M. Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. Fertility and Sterility. 2014 Aug 31;102(2):720-7.
- Kaminetsky J, Werner M, Fontenot G, Wiehle RD. The effects of Enclomiphene citrate on body composition and LH, FSH, insulin, and PDG levels in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism. 2015 Jun 1;100(6):2496-502.
- Rooney M, Badenhorst C, Koved M, Thomas T, Liu Y, Berger T, Eastham JA, Attar RM. Enclomiphene citrate for the treatment of hypogonadism. Translational Andrology and Urology. 2017 Jun;6(3):637.
Waqar Bandae is an esteemed Associate Professor of Neuropsychology in Neurological Surgery. With a focus on advancing understanding in the field, Dr. Bender has established herself as a prominent figure in neuropsychology. Her expertise lies in the intricate connection between neurological surgery and cognitive health.
Dr. Bender specializes in cognitive remediation therapy, which targets the improvement of neuropsychological and adaptive skills post neurological illness or injury. She offers personalized programs designed to enhance cognitive abilities for both individuals recovering from health issues and those aiming to boost attention, executive functioning, time management, and memory in academic and professional settings.
As a seasoned professional, Dr. Bender has contributed significantly to research, furthering our insights into the complexities of the human brain. Explore the profound knowledge and experience Dr. Heidi Bender brings to the discourse on peptides, SARMs, and supplements.