Selank is a synthetic peptide drug developed in Russia for the treatment of anxiety, depression, and other mood disorders. As a nootropic and anxiolytic agent, Selank has generated interest worldwide for its potential therapeutic benefits.
This comprehensive guide provides an overview of Selank, how it works in the body, its benefits and uses, proper dosages, and potential side effects.
With thoughtful and responsible use, Selank may offer a valuable addition to mental health regimens. However, more research is still needed to fully understand its long-term effects.
What is Selank?
Selank is a heptapeptide, meaning it is composed of seven amino acids. It is derived from tuftsin, a naturally occurring tetrapeptide in the human immune system. Selank’s full chemical name is Thr-Lys-Pro-Arg-Pro-Gly-Pro. The main difference from tuftsin is the addition of Proline-Glycine Proline to the sequence.
Selank was developed in the early 2000s by the Institute of Molecular Genetics in Moscow. Researchers were interested in tuftsin for its immune system stimulating effects but found it was broken down too quickly in the body to utilize fully. By adding amino acids to tuftsin to make Selank, they created a more stable version able to exert effects on the central nervous system.
The research team was led by Dr. Alexander Khidekel, who continued to study Selank’s effects. Research showed Selank’s potential for treating anxiety-depressive disorders, immune modulation, and neuroprotective capabilities.
Selank soon gained interest for its nootropic or cognitive-enhancing effects in addition to anxiolytic, antidepressant, and neuroprotective properties. It has been used in Russia for these purposes since 2014 when it was registered as a drug for anxiety and emotional disorders. However, clinical trials remain limited so more evidence is still needed.
Today, you can buy Selank online and locally as a supplement or nootropic. However, its legal status varies between countries. In the US, it is available for purchase as a research compound and is not approved as a drug or supplement. Regulations are less stringent in some other countries where you can buy Selank without a prescription.
How Selank Works in the Body
Research indicates that Selank provides its effects by influencing neurotransmitters and hormones in the body and brain. Here are some of the main ways Selank exerts its mechanisms of action:
- Increases serotonin – Selank has been found to increase levels of the key neurotransmitter serotonin. Serotonin regulates mood, sleep, appetite, and cognition. Low serotonin is linked to depression and anxiety. Selank may boost mood by elevating serotonin levels.
- Stimulates dopamine – Selank appears to stimulate the release of dopamine. This neurotransmitter is involved in focus, attention, learning, and feelings of pleasure or reward. Enhanced dopamine may account for some of Selank’s nootropic effects.
- Regulates cortisol – Cortisol is a hormone involved in stress responses. High cortisol is linked to anxiety, fatigue, low mood, and cognitive dysfunction. Selank may help regulate healthy cortisol levels to reduce anxiety and improve stress resilience.
- Immune modulation – Selank is thought to balance immune function. In some cases, it may stimulate the immune system. Its effects originate from tuftsin, which plays a role in immunity. More research is still needed on this aspect.
- BDNF support – Selank increases levels of BDNF (brain-derived neurotrophic factor). This protein supports nerve growth, brain plasticity, long-term memory, and cognitive function. Low BDNF is found in mood disorders.
These multifaceted mechanisms make Selank a versatile compound. The combination of effects on neurotransmitters, hormones, immunity, and nerve growth underlie its nootropic, anxiolytic, and neuroprotective properties. However, more clinical trials are still needed to confirm some of these mechanisms.
Benefits and Uses of Selank
Based on available research, anecdotal reports, and its mechanisms of action, Selank may offer various benefits:
Reduces Anxiety and Stress
Many users take Selank for its anxiolytic or anti-anxiety effects. Studies in animals and humans suggest that Selank decreases anxiety behaviors and distress under conditions of induced stress and anxiety. Users report lower social anxiety, improved relaxation, and an increased ability to handle daily stressors. Selank’s balancing effects on brain chemicals like serotonin and cortisol likely underlie these benefits.
Lifts Mood and May Help With Depression
By increasing serotonin, dopamine, and BDNF, Selank is thought to support a positive mood. There is interest in using it as an antidepressant medication, especially for people who do not respond well to traditional antidepressants. Early research found positive effects, but larger human studies are still needed. Anecdotal reports suggest that Selank can provide a mild lift in mood and outlook in healthy individuals.
Enhances Cognition and Memory
Selank is considered a nootropic due to its positive effects on learning, focus, cognition, and memory formation. Research links this to increased BDNF, dopamine, and blood flow in the brain. Users note better recall ability, quick thinking, concentration, and alertness when using Selank. It may benefit those with cognitive dysfunction, but more studies are warranted.
Supports Immune Function
Selank’s origins from the immune peptide tuftsin suggest possible immune regulating properties. Some evidence points to enhanced phagocytic (immune cell cleaning) activity and immunoglobulin synthesis. However, immune effects may depend on the current immune environment. More research is still needed to clarify Selank’s effects on immune parameters in humans.
Early studies indicate that Selank supports neuronal health and protects against cell damage in the brain. It was found to reduce the effects of oxidative stress and cell death signals. The increase in BDNF from Selank also promotes nerve growth and plasticity. These neuroprotective mechanisms may help preserve cognitive function and mental health.
Interestingly, animal research found that Selank decreases alcohol withdrawal symptoms and the desire for alcohol. This may be due to the modulation of serotonin and dopamine—two neurotransmitters heavily impacted by alcohol use. More research is needed, but Selank could potentially aid in alcohol addiction treatment.
These benefits make Selank a promising compound. However, rigorous large-scale human studies are still lacking for many of these potential uses. Anecdotal user experiences are widely available online but should be interpreted with caution until more evidence is available. Selank’s nootropic and anxiolytic properties appear most promising currently.
Proper Selank Dosage
Selank is not currently approved as a drug or supplement. It is usually purchased as a powder and prepared in a nasal spray. This allows for convenient dosing of just a few milligrams by spraying in the nose.
Typical Selank dosage ranges are:
- Nootropic use – 200-400 mcg per day
- Anxiolytic use – 400-1,000 mcg per day
- Antidepressant use – 1,000-1,500 mcg per day
Doses are often divided into twice per day administration—once in the morning and once early afternoon. This provides symptom relief while avoiding interference with sleep.
It is best to start at lower doses like 200 mcg and assess tolerance before increasing the dosage. Effects can often be felt within 30 minutes due to the nasal administration.
Cycle lengths of 4-6 weeks are commonly followed to avoid building up too much tolerance. Taking 2 weeks off in between cycles allows the body’s sensitivities to reset.
Dosage frequency and size should be tailored to the individual based on their needs and response to the compound. Effects can vary substantially between users. Working with a knowledgeable practitioner is recommended for best results especially if using Selank for mood disorders or alcohol use disorders. Proper precautions should be taken when handling and using Selank powders.
Side Effects and Safety Concerns
Selank has a relatively low side effect profile in research studies and anecdotal reports. However, there are some potential side effects and considerations:
- Headaches – Some users report headaches, especially when starting Selank. Staying hydrated can help minimize headaches.
- Stimulation – Selank may cause overstimulation at higher doses leading to anxiety, agitation, and insomnia. Start low and increase dosage carefully.
- Dependence – There are limited reports of dependence and withdrawal with frequent high-dose use. As with any psychoactive substance, responsible use is advised.
- Nasal discomfort – Chronic nasal administration may cause dryness, irritation, inflammation or congestion. Using a saline nasal spray can help alleviate these issues.
- Immune effects – Selank affects immune parameters but further research is still needed on these specific effects. Those with autoimmune conditions or allergies should use caution.
- Interactions – Selank likely interacts with serotonergic drugs, alcohol, immunosuppressants, and psychiatric medications, but clinical interaction data is unavailable. Use care when combining it with any medications.
- Long-term effects – As a relatively new drug, Selank’s long-term effects have not been well-studied. Effects beyond 6 months are currently unknown. Periodic breaks from use are recommended.
- Legality – Laws surrounding Selank vary between countries. In the US it is only sold for research. Large purchases can be flagged by customs. Users must research their local laws.
- Quality control – There are risks when obtaining pharmaceuticals outside regulated channels. Seek reputable suppliers providing purity testing. Poor quality or impure product increases the risk of side effects.
While considerably safe when used responsibly, Selank still carries some risks like any psychoactive substance. It should not be combined with medications or used excessively due to a lack of formal safety data. Those struggling with mental health conditions should work with a professional and not solely rely on Selank.
Selank vs Noopept
Selank and noopept are two popular nootropic supplements, but they differ in some key ways:
- Selank is a synthetic peptide developed in Russia derived from the immune system peptide tuftsin.
- Noopept is a synthetic small-molecule peptide supplement originally synthesized in Russia.
- Selank is typically administered intranasally via nasal spray that allows the peptide to absorb into the bloodstream.
- Noopept is usually taken orally in pill or powder form. It has low oral bioavailability.
- Selank primarily influences serotonin, dopamine, cortisol, BDNF, and immune function.
- Noopept mainly stimulates glutamate, acetylcholine, and BDNF in the brain.
- Selank is used for its anxiolytic, antidepressant, and mild cognitive enhancement effects.
- Noopept is taken for its cognitive enhancement abilities like improved learning, focus, and memory formation.
- Selank dosage ranges from 200-1500 mcg per day.
- Noopept dosage is 10-30 mg taken 1-3 times per day by most users.
- Selank has fewer reported side effects but long-term safety data is limited.
- Noopept has a low risk of side effects at standard dosages besides occasional headaches.
- Selank is unregulated in most countries and sold as a research compound.
- Noopept is also largely unregulated but more commonly sold as a dietary supplement.
- Selank has promising research but lacks large-scale human trials.
- Noopept has more studies demonstrating cognitive enhancement abilities.
In summary, Selank and noopept are both intriguing Russian-developed nootropic supplements with different mechanisms of action, administration, effects, safety, and legal profiles. Selank appears more specialized for anxiety, depression, and mood, while noopept is catered to cognitive enhancement like memory and learning.
Does Selank Come In A Pill?
No, Selank is not currently available in pill form. The peptide structure of Selank makes it unstable and ineffective if taken orally.
Selank is always administered intranasally via nasal sprays or drops. This allows it to bypass digestion and absorb directly into the bloodstream for effects.
Researchers have not yet developed a capsule or pill that can sufficiently protect Selank from degradation in the stomach.
Is Selank Safe?
Research indicates that Selank appears relatively safe at recommended dosages when used carefully and in moderation. No serious adverse effects have been found in studies.
However, large-scale human trials are still lacking, so more data is needed on long-term safety with prolonged use. Like any psychoactive substance, Selank carries risks if abused consistently at high doses.
It also has some interactions with certain medications. Responsible usage and avoiding combinations with pharmaceutical drugs can help reduce any risks of Selank.
Working closely with a medical professional is advised, especially when taking Selank for mental health conditions.
Frequently Asked Questions
Can Selank be stacked with other nootropics?
Selank is often stacked with other nootropics like phenylpiracetam, aniracetam, arginine, and ubiquinol. Many users find these combinations provide synergistic cognitive enhancing effects. However, Selank’s interactions are not fully characterized so caution is advised when combining with other compounds, especially serotonergic substances. Start with low doses to assess tolerance.
Does Selank build up a tolerance?
Yes, tolerance builds with regular usage of Selank after 1-2 months for most users. This leads to reduced effects and the need for higher dosages over time. To avoid building up a tolerance, it is recommended to cycle Selank for 4-6 weeks and then take 1-2 weeks off. Resetting tolerance helps retain effectiveness over the long term. Proper cycling is key for continued benefits.
What is the legality of purchasing Selank?
In most countries, Selank is not approved as a drug or supplement. However, regulations for research compounds vary. In the US, it can be purchased online legally as a research peptide only. Importing for personal use in moderate quantities is typically allowed. Large purchases may be flagged and confiscated, however. Laws differ between countries so research local regulations before obtaining Selank.
Can Selank enhance exercise performance?
Some anecdotal reports suggest Selank provides modest stimulant-like effects increasing energy and endurance for workouts. However, there is currently no research on direct ergogenic or performance-enhancing effects. More evidence is needed to verify if Selank can boost athletic efforts or endurance like some traditional stimulants. Effects likely vary widely between individuals.
How addictive is Selank?
Selank does not appear highly addictive, but psychological dependence can occur with excessively high doses. Its effects on serotonin, dopamine, and cortisol influence brain pathways involved in addiction and cravings. Proper cycling and avoiding consistently high doses reduces addiction risks. Those with addictive tendencies should exercise additional caution when using Selank or other psychoactive substances.
As a novel peptide drug, Selank offers intriguing possibilities for improving mental health, cognition, stress resilience, and brain function. Research continues to unfold on its complex mechanisms of action influencing neurotransmitters, hormones, immunity, and neuroplasticity. Early clinical evidence and anecdotal reports suggest that Selank has nootropic and anxiolytic properties with relatively mild side effects.
However, Selank is still an experimental compound requiring further study to clarify optimal uses and safety. Responsible and informed use is imperative, especially given its unregulated legal status in many countries. Appropriate cycling, dosing, stack combinations, and monitoring for side effects allow Selank to be used as a beneficial adjunct. For those interested in trying Selank, it’s essential to exercise caution and consider obtaining it from reputable sources when looking to purchase peptides online. But expectations must be tempered until more definitive human trials are completed.
For individuals struggling with mood disorders, Selank should be seen as an additional aid and not a replacement for professional medical care and established treatments. Combined with a healthy lifestyle and evidence-based care, Selank offers promising possibilities for improved mental health and brain function. However further research is critical to elucidate the clinical potential of this unique Russian-developed peptide.
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