Chemical Structure:
Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular formula: C46H56N12O6
Molar Mass: 873.014
CAS number: 87616-84-0
PubChem: 5486806
Studies on GHRP-6 Peptide
Studies have shown that GHRP-6 is more potent than GHRH when used in monkeys, and it is also more effective when used in combination with other peptides. An investigation revealed that GHrP-6 acts naturally on both pituitary and hypothalamic sites. Experiments were carried out on the primary pituitary cells of rats. The maximum and minimum stimulation of GHRP-6 concentration were 7 x 10-9M and 10-7 M, respectively.
Another study revealed that GHRP-6 mainly targets the hypothalamus in both laboratory animals and humans. The study showed that somatostatin inhibited the action of GHRP-6 and prevented GH release. Furthermore, the actions of somatostatin on the GRF neurons, induced by GHRP-6, were observed via receptors close to the GRF. This study proved that GHRP-6 stimulates GH release from somatotrophs via various receptors.
The full extent of how efficient the growth hormone is depends on the medium of the experiment. For instance, GH secretion is reduced by obesity in humans. However, GHRP-6, in one experiment, showed an increase in obesity. Although obesity can be considered an efficiency factor for GHRP-6, the main factors are sex and age.
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