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AICAR (Acadesine) is an intriguing peptide still under investigation for its effects on metabolic regulation. It works by directly activating AMP-activated protein kinase (AMPK), an enzyme that controls energy homeostasis within cells.
AMPK gets switched on in response to a low energy status in order to boost energy production. By directly stimulating AMPK, AICAR is able to modulate glucose uptake, fatty acid metabolism, mitochondrial function, and other processes related to metabolism and endurance capacity.
The main mechanism of action of AICAR is the activation of AMPK. Specifically, it mimics AMP, which normally binds to and alters the structure of AMPK to activate it when cellular energy is low.
This activation stimulates processes that increase energy production and reduce energy utilization. In addition, AICAR may inhibit an enzyme called fructose-1,6-bisphosphatase, which normally promotes gluconeogenesis. This could aid in reducing blood glucose levels.
Research has shown AICAR may provide benefits related to athletic performance, weight loss, blood glucose regulation, cholesterol levels, and more. In studies on mice, AICAR increased running endurance by 44% and activated genes involved in running performance. It also reduces body fat mass.
In humans, AICAR increased insulin sensitivity and glucose uptake in those with type 2 diabetes. It also reduces blood triglycerides and LDL cholesterol. More research is still needed, but the current findings are promising.
AICAR is sold in powder form that can be reconstituted with bacteriostatic water to create an injectable solution. The standard dose used in research is 500mg per injection. Since it is still an experimental peptide, there are no set dosage guidelines, and it should only be used under medical guidance.
The powder is stable for around 2 years when properly stored away from sunlight at a controlled room temperature. Once reconstituted, the solution should be kept refrigerated and used within a week.
As research peptides are not approved for human use, AICAR is only available from specialty peptide suppliers and research companies. When looking to buy peptides online, be sure to use a reputable company that provides third-party purity testing and quality assurance. Only purchase pharmaceutical-grade AICAR from trusted sources.
Overall, more clinical trials are still needed to fully validate the benefits and risks of using AICAR peptides. However, preliminary research shows promising effects that warrant further investigation. Those looking to buy peptides like AICAR for research purposes can find high-quality compounds through reputable online suppliers.
