Andarine S4

Andarine S4 – Guide to Effects, Dosing, Cycles and Side Effects

Last updated on November 22nd, 2023 at 07:07 am

Andarine S4, also known as acetamidoxolutamide, is a popular selective androgen receptor modulator (SARM) that has been widely used to improve physique and performance.

With its potent anabolic effects and relative safety compared to steroids, S4 has become a staple compound for everything from cutting fat to bulking muscle.

In this in-depth guide, we’ll cover everything you need to know about using Andarine S4 effectively and safely for your goals:

Chapter 1: What is Andarine S4 and How Does it Work?

Andarine is part of the SARM family of performance-enhancing drugs. SARMs provide anabolic, muscle-building effects like steroids, but with higher specificity and reduced side effects.

S4, in particular, was originally developed by GTx Inc. for the treatment of muscle-wasting diseases, osteoporosis, and benign prostatic hypertrophy. If you’re interested in buying Andarine S4, you can find reputable sources that offer this remarkable SARM for enhancing muscle growth and overall well-being.

Mechanism of Action

  • Like other SARMs, Andarine S4 exerts its effects by binding to and activating your body’s androgen receptors.
  • Androgen receptors are activated by the hormones testosterone and DHT and play a key role in muscle growth and fat loss. SARMs activate the same pathways without converting to estrogen or impacting the prostate.
  • Once S4 binds to androgen receptors, it triggers increased protein synthesis and nitrogen retention. More protein synthesis = more muscle growth.
  • It also stimulates lipolysis, the breakdown of stored fats for energy. This is why S4 can help boost fat burning, especially when cutting.
  • Some scientists believe S4 may reduce the expression of lipoprotein lipase, an enzyme important for fat storage. This can further contribute to its fat-burning abilities.
  • In studies on animals, scientists also observed that S4 increased the number of muscle satellite cells – the stem cells needed for muscular repair and growth. This can result in enhanced muscle endurance.
  • Unlike traditional steroids, S4 does not aromatize into estrogen or raise prolactin levels. This helps avoid many of the side effects associated with excess estrogen or prolactin.
  • The end result is an oral SARM that boosts muscle mass and endurance, shreds fat, and avoids prostate issues…with fewer side effects than illegal steroids.
  • Next, we’ll explore the benefits of Andarine in detail…

Chapter 2: Andarine S4 Benefits For Bodybuilding and Athletes

Andarine S4 is prized in bodybuilding, powerlifting, and other strength sports for the following benefits:

1. Lean Muscle Gains

The most obvious benefit of Andarine for any athlete or bodybuilder is its ability to promote lean muscle growth.

Multiple studies confirm that S4 stimulates muscle mass even in the absence of exercise or weight training.

In one study, participants taking S4 gained 2-3lbs of lean body mass in only 28 days…without lifting weights!

In another trial, scientists observed that S4 prevented any decreases in lean muscle weight during calorie restriction – preserving muscle even in a harsh cut.

Anecdotal experiences by bodybuilders show Andarine allows them to gain 10-15lbs of lean dry mass during an 8-12 week cycle. It’s especially valued for helping retain mass while leaning out.

The upside is that Andarine provides solid lean muscle gain with little to no water retention or puffiness. Gains are dry, high-quality mass.

2. Enhanced Fat Loss

In addition to its muscle growth properties, Andarine exerts a powerful cutting and shredding effect by accelerating fat loss.

It does this through several mechanisms:

  • Increasing fat cell lipolysis
  • Suppressing lipoprotein lipase enzyme responsible for fat storage
  • Increasing fat oxidation for energy

Users report body fat percentage drops of 2-4% within only 8-10 weeks of taking S4, provided diet and training are dialed in.

It’s an extremely popular addition to cutting stacks and recomposition cycles thanks to its dual muscle-building and fat-burning attributes.

3. Boosted Strength

Gaining slabs of new muscle tissue will obviously translate into increased strength gains.

But beyond that, studies confirm that S4 also boosts muscular endurance and power output.

In several trials, participants were able to lift more weight and had higher endurance during bouts of intense exercise after taking S4.

These performance-boosting effects give you the Superman feeling in the gym – moving more weight for more reps.

Strength gains of 20-30 lbs on major lifts in the first cycle are not uncommon. This can continue improving in subsequent cycles too.

4. Joint and Tendon Relief

An intriguing benefit of Andarine not shared with traditional steroids is its ability to strengthen bones and connective tissue.

SARMs like Andarine have been shown to increase collagen synthesis and bone mineral density in studies.

This results in joints, tendons and bones that are primed to handle heavier weights and more intense training.

Many users find their nagging gym injuries, tendonitis or joint pain improves while taking S4. Ligaments also feel enhanced.

For athletes and powerlifters especially, this allows them to train harder and lift heavier weights pain-free, smashing PRs week after week.

Andarine S4

5. No Estrogen Conversion

A major concern with steroid use is excess estrogen from the conversion of compounds like testosterone into estrogen.

Elevated estrogen brings side effects like water retention, enlarged breasts (gyno), and excess body fat accumulation.

The non-steroidal SARMs like Andarine do NOT aromatize into estrogen or raise prolactin levels.

S4 avoids that dreaded puffy look and won’t cause enlarged or sensitive breasts in men. This makes it far more side-effect friendly.

For female athletes wary of virilization, S4 represents a safer alternative to steroids that provides anabolic effects with female-friendly compounds.

Chapter 3: Andarine Before and After – Realistic Results Timeline

Andarine (S4) is not a miracle drug on its own. To maximize results, it must be used alongside proper nutrition, training, cycle planning, and post-cycle therapy (PCT).

Keeping expectations realistic is also important. Genetics, training years, diet, and dosage all impact results.

Here’s a general idea of the Andarine results timeline:

Month 1:

  • 3-7 lbs of lean muscle gain
  • 2-4% drop in body fat
  • Increase of ~10-20 lbs on compound lifts
  • Improved endurance for more volume and intensity
  • Some visual changes in muscle fullness, veins, and vascularity

Month 2:

  • 4-10 lbs additional lean muscle
  • Continued fat loss around the midsection and hips
  • Strength into new PB range on lifts
  • Faster recovery for more frequent workouts
  • Increased muscle hardness, thickness, and separation

Month 3:

  • 5-15 lbs total lean mass gain
  • 4-6% body fat reduction overall
  • PRing regularly on main lifts
  • Visually bigger and leaner muscles
  • Clear muscle definition and striations
  • Vascularity increase

These types of results require intensive training, high protein intake (at least 1 gram per lb of body weight daily), and appropriate caloric intake. S4 amplifies the effects of diet and training – it does not replace them.

A typical S4 cycle lasts 8-12 weeks for best results. We’ll break down exactly how to dose Andarine for cutting, bulking, or coming next.

Chapter 4: Andarine S4 Dosages and Cycles

Andarine is commonly dosed anywhere from 25mg to 75mg per day. Higher doses have been tested in clinical settings without appreciably increased side effects.

However, 50mg daily or less is ideal for most. Anything over 75 mg will rarely provide additional benefits.

Cycles typically last 8-12 weeks; an 8-week cycle is sufficient for most users to achieve their goals.

Here are guidelines for Andarine dosages tailored to your goal:

Cutting and Fat Loss Dosage

When the primary aim is cutting fat and maintaining muscle, 25 mg daily is recommended. This is enough to experience enhanced fat-burning, strength, and endurance without significant muscle gain.

The total cycle length can be 6-8 weeks. Andarine stacks well with other cutting SARMs like Cardarine or SR9009 during this period.

Women can opt for 12.5mg-25mg per day for fat loss cycles.

Lean Bulking and Muscle Building Dosage

For pure muscle-building cycles, 50mg of Andarine for 8 weeks is ideal. This will maximize your lean muscle gains.

Some go as high as 75 mg, but side effects may increase beyond 50mg without much added benefit.

Adding other wet SARMs like LGD-4033 during a bulk can complement Andarine’s dry gains.

Recomposition Dosage

If the goal is simultaneous fat loss and muscle gain, start with 25mg-50mg of Andarine for the first 4 weeks.

The dosage can be increased to 50-75mg for the remaining 4-8 weeks as your body adapts. This will provide a balance of cutting and bulking.

Don’t extend beyond 12 weeks total cycle length as diminishing returns make it less effective for long-term uninterrupted use.

Always use a proper PCT supplement protocol after S4. More details shortly on how to do this.

Now let’s explore how to combine Andarine with other SARMS for maximum results…

Chapter 5: Andarine S4 Stack Ideas and Cycles

While potent on its own, Andarine becomes even more effective when combined with other SARMs in a stack.

Stacking compounds that complement each other provides synergistic benefits. It can also help keep side effects in check.

Here are some of the best Andarine S4 stack options:

Andarine and Cardarine Stack

Andarine + Cardarine is likely the most popular stack for cutting and fat loss.

Cardarine (GW-501516) speeds up metabolism and ignites intense fat oxidation. It provides nearly unlimited endurance too.

When combined with Andarine’s abilities to improve muscle mass and strength while stripping away body fat, it’s a dual threat that forces the body to shed stubborn pounds of body fat rapidly.

An 8-week cycle of Andarine 25mg + Cardarine 20mg daily is very effective for this purpose. Dosages can increase slightly in the last 4 weeks. This stack does not require PCT.

Andarine and RAD-140 Stack

RAD-140 (Testolone) is another SARM that boosts strength, endurance, and muscle building much like Andarine.

When both are stacked together, users often report RAD-140’s effects are amplified for even better muscle gains and fat loss.

A typical cycle would be 6-8 weeks of Andarine 50mg + RAD-140 20mg daily. This stack would require a standard 4-week PCT after discontinuing.

Andarine and LGD-4033 Stack

LGD-4033 (Ligandrol) is arguably the most powerful mass-building SARM. It delivers rapid strength and size increases.

It can cause some water retention, however, so stacking it with the dry gains of Andarine gives a great balance of wet and dry muscle.

Run LGD-4033 10mg for 8 weeks alongside 50mg Andarine to capitalize on their combined anabolic properties. Have PCT prepared.

Andarine, RAD-140 and LGD-4033 Triple Stack

For advanced users, a combination of Andarine, RAD-140, and LGD-4033 together allows maximal muscle growth with accelerated fat loss.

A typical 8-week triple SARMs stack is 25mg Andarine, 10mg LGD-4033, and 10mg RAD-140 per day. More advanced lifters may opt for 50mg of Andarine. PCT is strongly recommended after this intense stack.

There are limitless options for combining compounds, but these basic stacks offer a great starting point.

Next, we’ll examine the potential side effects of using Andarine so they can be minimized…

Chapter 6: Andarine S4 Side Effects and Safety

Compared to illegal steroids, SARMs like Andarine are much safer with minimal side effects. Especially at moderate doses of 50mg or less per day.

However, there are some temporary side effects that can occur:

Vision Changes

The most common side effect reported with Andarine S4 use is temporary vision changes.

Users describe seeing a yellowish tint which is most noticeable at night or going from a light to dark environment. It looks similar to wearing yellow-lensed glasses.

This is caused by S4’s mild interaction with retinal tissue. It may slightly change color perception for some.

These vision changes fade within 12-24 hours of stopping S4. They are harmless and visions return to normal immediately after discontinuing use.

Suppressed Natural Testosterone

Like other performance enhancers, S4 may suppress your natural hormone production, including testosterone.

This is because your body detects excess androgens in your system and reduces natural production.

Symptoms like low libido, energy, or strength can occur. This is temporary and can be avoided with proper PCT.

Increased Aggression

Some users report increased aggression or irritability within the first few weeks of taking Andarine.

This tends to diminish as the cycle continues and your body adapts. Keeping estrogen balanced with a supplement like DIM can help.


Rarely, headaches are reported at the onset of an Andarine cycle. Staying hydrated helps minimize this. They typically subside within a week or so.

Aside from these minor nuisances, Andarine exhibits a very favorable safety profile with no organ toxicity or deleterious long-term effects.

Proper precautions also minimize the small risk of side effects:

Use Lab Tested Source

Only purchase pharmaceutical grade Andarine from a reputable source and lab test for purity. This avoids bunk or contaminated products.

Moderate Dosing

Keep dosages reasonable at 50mg per day or less. There is rarely any benefit beyond this point.

8 Week Max Cycle Length

Limit total Andarine use to 8 weeks. After this point, hormonal suppression may increase.

Post Cycle Therapy

Use over-the-counter PCT supplements to restore natural hormone function after longer cycles.

Get Bloodwork

Blood tests assess hormone status if symptoms like low libido arise indicating testosterone suppression.

Provided these simple precautions are taken, Andarine side effects are mild and temporary for most.

Andarine S4

Chapter 7: Fitness and Nutrition Protocol On Andarine

To maximize the results from Andarine, your exercise and nutrition program must be adapted to work synergistically with it.

Here are some tips:

Heavy Compound Lifts

Focus workouts around heavy, compound barbell lifts like squats, benches, deadlifts, rows, and overhead presses. Go heavier on these as strength increases.

Train 4-5 Days Per Week

Andarine allows increased training frequency and volume due to more rapid recovery. Optimize this with 4-5 lifting sessions per week.

High Volume and Intensity

Higher volume, moderate rep sets (5-8 reps) ensure the most muscle damage and growth stimulus occurs. Push intensity.

Cardio 2-3 Times Weekly

Incorporate some form of cardio or conditioning 2-3 days per week for optimal fat burning, especially when cutting. Don’t overdo it though.

High Protein Intake

Consume plenty of protein – 1 to 1.5 grams per lb of body weight daily – to fuel muscle growth. Whey, casein, meats, fish, eggs, and dairy work well.

Moderate Carbs

Carbs help fuel intense workouts and fill out muscles. 2-3g per pound of body weight daily is a good starting point to gauge needs.

Healthy Fats

Omega fatty acids, nuts, olive oil, avocados, and fatty fish provide the building blocks for muscle gain and hormone production. Get at least 20-30% of total calories from these healthy fats.

Caloric Surplus on Bulk, Deficit When Cutting

Adjust calories appropriately – increase slightly when bulking up, reduce when leaning out – based on your goals and metabolism.

Stay Hydrated

Drink plenty of water, at least 1 gallon daily, to stay hydrated and minimize any potential headaches or vision issues.

With an appropriate fitness and nutrition plan tailored to your goals, Andarine will supercharge your results.


Andarine S4 is a game-changing SARM that can safely boost muscle growth and fat loss to help you attain an outstanding physique and performance. If you’re looking to purchase peptides online to complement your SARM regimen, you’ll find a wide selection of high-quality products to support your fitness journey.

It provides steroid-like results in terms of strength, endurance, and muscle gains without the harsh side effects of illegal anabolic steroids.

Dosing Andarine at 25mg-50mg per day in 8-week cycles provides exceptional benefits like:

  • 10-15lbs of lean, dry muscle gain
  • 4-6% reduction in body fat
  • Increased strength for heavier lifts and endurance for more volume
  • Joint relief and connective tissue strengthening
  • Excellent for both cutting and bulking cycles

Andarine delivers reliable results quickly, especially when nutrition and training are optimized to complement its effects.

Used intelligently with proper PCT, it’s one of the safest, most effective SARMs for transforming your physique and ability to new heights.

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